Mixed or immune complex cryoglobulinaemia and neuropathy.
نویسندگان
چکیده
Three patients with peripheral neuropathy and mixed or immune complex cryoglobulinaemia are reported. The significance of mixed cryoglobulinaemia and the pathogenesis of the peripheral neuropathy are discussed.
منابع مشابه
Successful Treatment of Cryoglobulinaemia with Rituximab
Cryoglobulinaemia is a systemic inflammatory condition characterised by immune complex-mediated small-to-medium-sized vasculitis. It has a wide variety of presentations ranging from bruising, neuropathy, and hepatosplenomegaly to acute renal failure. Mixed cryoglobulinaemia is the most common type and is strongly associated with hepatitis C. Management approaches include use of cyclophosphamide...
متن کاملHepatitis C virus infection with peripheral neuropathy is not always associated with cryoglobulinaemia.
OBJECTIVES To describe cases of peripheral neuropathy associated with chronic hepatitis C virus infection without mixed cryoglobulinaemia. METHODS Four cases of peripheral neuropathy associated with chronic hepatitis C virus infection with persistent negativity of mixed cryoglobulinaemia were found. RESULTS All patients had small increases of transaminase levels and a positive viraemia. Liv...
متن کاملCryoglobulinaemia induced digital gangrene in a case of hepatitis C.
DESCRIPTION A 65-year-oldwoman presentedwith severe pain in the fingers of both hands (figure 1). The patient was diagnosed with hepatitis C virus (HCV), following blood transfusion 30 years ago, and had developed the associated pathologies of cirrhosis and cryoglobulinaemia. Over the past 7 years, she had required multiple hospital admissions to treat associated complications. These consisted ...
متن کاملCoeliac disease, vasculitis, and cryoglobulinaemia.
Four patients are described with the association of adult coeliac disease, vasculitis, and cryoglobulinaemia. In each patient the cryoglobulinaemia was of the mixed type consisting of more than one immunoglobulin class. It is suggested that the mixed cryoglobulins represent circulating immune complexes and that their deposition in small vessels causes the vasculitis. This is supported by immuno...
متن کاملThe cryoglobulinaemias.
Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures less than 37°C and produce organ damage through two main pathways: vascular sludging (hyperviscosity syndrome, mainly in type I cryoglobulinaemia) and immune-mediated mechanisms (principally vasculitis, in mixed cryoglobulinaemia). Cryoglobulinaemia is associated with many illnesses, which can be broadly grouped into in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 37 1 شماره
صفحات -
تاریخ انتشار 1974